Research
High-resolution NMR spectroscopy and biophysics of proteins
The biophysics group of the Martin-Luther-University of Halle-Wittenberg studies biomolecules by high-resolution NMR-spectroscopy on, investigates the biophysics of protein folding, and employs time-resolved NMR-spectroscopy to follow protein reactions. With these methods we characterize on the one hand the formation of structures as well as the correlation between structure, dynamic and function of proteins and their target molecules. On the other hand we aim towards a molecular understanding of pathogenic malfunctions of protein related diseases.
Fields of research
- Structure determination of proteins
- Dynamics of proteins
- Biophysics of protein folding
- Post-translational protein modifications
- Amyloid fibrils (Alzheimer peptide, parathyroid hormone)
- Dynamic of aromatic side chains in proteins - Ulrich Weininger
Funded projects and research networks
- German Research Foundation (DFG) –Research Unit5433 “RNA in Focus (RIF): From mechanisms to novel concepts in cancer treatment"
- German Research Foundation (DFG) – Research Training Group (RTG) 2467 "Intrinsically Disordered Proteins – Molecular Principles, Cellular Function and Diseases"
- German Research Foundation (DFG)– Research Centre Transregio 102 "Polymers under multiple constrains: restricted and controlled molecular order and mobility"
- German Research Foundation (DFG) - Collaborative Research Center 1664 "Plant Proteoform Diversity - SNP2Prot
- Middle German Center for structure and dynamic of Proteine (MZP)
- Center for Innovation Competence HALOmem "Membrane Protein Structure & Dynamics"
- EFRE